Debilitating states of physical suffering, cognitive suffering, and affective suffering may need intervention.
The aim of psychotherapy (at its best) is to address the debilitating forms of affective suffering. To pine for one's loved one is not a fit case for psychiatric intervention. It is considered normal, and healthy. When you do nothing but pine, however, intervention may be required.
Suffering can be endured more easily if there seems to be a meaning behind it. The grand theories of Karma, the big picture, divine justice, Our Father in Heaven, are all ways to make the unendurable endurable. The realization that it is all a lot of sound and fury, signifying nothing, may and does lead to insanity and suicide.
However, it is a momentous error to see this sorry state of affairs (pain and its palliatives) and to want to eradicate both the pain (the passion) and the palliatives (beliefs). With the eradication of both, in toto, there is no debilitation, but there is no movement either.
Motivation is affective. Cognitive or intellectual motivation is woefully insufficient, as any manager or leader worth his name will tell you.
As Wittgenstein said in words to this effect: To solve all problems of humanity is to be standing on ice. There is no friction, but there is no possibility of moving ahead as well.
To be without the affective push is also therefore debilitating.
The lack of affective faculty is a state of dysfunction requiring psychiatric intervention, if others depend on you. While normal life is indeed pathetic, the affect-less life is apathy. This apathy may be couched in glorious terms, but it is what it is.
What can curiously happen in a state of apathy, given an ethical framework which glorifies such behavior, is a regression to sensuality and hedonism, the state of a child. "Oh look at those bright colors!" "Oh look at this shiny new gadget!" In the absence of sensual or short-term stimulation and distraction, an apathetic individual has literally nothing to live for. Hence, depression, boredom, ennui.
The lasting cure for depression is not sensuality, but meaning.
The modern man is afflicted with a lack of meaning and feeling (to varying degrees), and is stuck at stimulation. It is not his fault, of course. The whole culture of consumption and glitter is pushing this paradigm of being concerned with nothing but me, here-and-now. Narcissism and hedonism are all around us. People are dying to feel connected again, but are unable to. The others with whom one craves connection are immersed in themselves as well.
Emptiness and depression is the inevitable result of a lack of meaning. If somebody is happy, look for where he is getting his fix of meaning. He may say he has no beliefs, but look closer.
Do not be quick to snatch/destroy somebody's belief, one which gives him meaning. Let him be, you have only another belief, another meaning which you believe is truer, to offer in return. And if you don't offer anything in return, you have done him a disservice.
If a man kills while defending his belief, understand that he is killing for what gives his life meaning. You may find him barbaric, but he doesn't have your advanced beliefs which cannot be attacked except by a thesis-length tome. His beliefs are easy to attack, and therefore he attacks easily.
The strongest sense of meaning is one which cannot be attacked or threatened even in principle. Spiritual people are notoriously immune to criticism, because their sense of meaning is highly, highly subjective and you cannot attack it easily. Even the means of discourse (intellection) is decried right at the beginning. It is a good trick. It is as if you are asking a debater to cut out his tongue and then talk.
Something which goes beyond traditional spirituality (i.e a meme which is more immune) will have to consist of an even stronger belief system which is more in tune with modern science, etc.
A total lack of meaning, a deep sense of tragedy, is the inescapable state of an aware and authentic man. Anything else is dishonesty or a distraction.
And hence, someone who wishes to live authentically is bound to suffer.